A same-day flight run needs an early outbound and an afternoon return, with enough gap between them that a delayed inbound does not sink the whole plan. A realistic version:
05:00 arrive at Tan Son Nhat, check in for the early flight. You get your Vietnam exit stamp when you clear departure immigration.
07:00 depart. One hour in the air, no time zone change.
08:00 land at Techo. Clear Cambodian immigration, pay the visa on arrival at the counter if you need one, roughly 30 USD for most nationalities.
09:30 back at departures, check in for the return flight. The airport is the waiting room for the next two hours.
12:00 depart KTI, land at Tan Son Nhat around 13:00.
13:30 clear Vietnam immigration on your new e-visa, grab the pre-arrival QR code if the officer asks, and you are out by 15:30 at the latest, back in District 1 around 16:00.
That is roughly 11 hours from your doorstep to your doorstep, and it assumes the flights run on time. The margin for error lives in the middle of the day, which is why an overnight version in Phnom Penh is the more relaxed option: fly out in the evening, sleep, fly back the next morning. The hotel costs 25 to 60 USD, and the run stops feeling like a race.